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Additionally, vernoniosides and 3-deoxyvernodalol exhibited antiinflammatory activity, while hydroxyvernolide and 6,10,14-trimethylheptadecan-15-olyl-15-O--D-glucopyranosyl-1,5-olide have shown anti-DM potential (548, 550)
Neuroinflammation and the immune system Microglia mediate the immunomodulatory processes in the brain and play a crucial role in the neuroinflammation in PD, leading to chronic activation and releasing of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-) and interleukin-1 beta (IL-1), which further increase the damage in neurons and promote disease progression 41
This study has several limitations, in addition to the need for a longer observation period, a larger sample size is required in future studies to explore the optimal dosage of DPSC injection for each stage of periodontitis
However, HPLC analysis can be a costly endeavor, which inspired the development of electrochemical methods
